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KMID : 1084220190260040278
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Journal of Rheumatic Diseases
2019 Volume.26 No. 4 p.278 ~ p.281
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A Case of Rapid Progressive Neurosyphilis in Patient with Ankylosing Spondylitis Who Is Treating Anti-interleukin 17A Monoclonal Antibody, Secukinumab
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Lee Sang-Jin
Park Han-Ki
Kim Yong-Sun
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Abstract
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Anti-interleukin 17A agent, secukinumab is remarkably effective for treating patients with ankylosing spondylitis. However, the main safety concern of secukinumab is an increased risk of infection. Generally, neurosyphilis occurs a few years after the primary syphilitic infection. Rare cases of progressing to neurosyphilis with a much lower latency were reported. We report a case of rapid progressive neurosyphilis involving hearing loss in both ears in a patient with ankylosing spondylitis who was treated with secukinumab.
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KEYWORD
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Ankylosing spondylitis, Interleukin 17A, Neurosyphilis
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